With the rapid growth of population in Westchester County, especially in the vicinity of White Plains, the need arose for suitable schools that would prepare students to take their place in the business, social, and cultural life of the County. Maria Regina High School was founded in 1957 by the late Francis Cardinal Spellman as the First Archdiocesan Catholic High School for girls in Westchester County. The school is located on a historic spot of land where, in July of 1781, the French troops under the Compte de Rochambeau encamped, assisting General Washington to the south and west to threaten the British holdings in New York.

The former Bingham estate was purchased by the Archdiocese in the spring of 1957. Preparations were begun immediately to renovate the entire building to make it suitable for a temporary high school and also a convent for the Sisters of the Resurrection who staff the school. Sister Mary Gertrude, C.R. was appointed the school's first principal. Sister's dedicated leadership, competent planning and organizational ability served as the basis of all future developments of Maria Regina High School.

Maria Regina is under the administration of the Sisters of the Resurrections. The faculty is comprised of fully qualified religious and lay teachers. The Counseling staff includes three academic counselors, a student advisor, and a Campus Ministry Team.